refraction of light. This biconvex lens has a diameter cm with a focal length of 10 cm. Product Code EISV. MTA Catalogue page: Description. When the voltage of the pulse is increased above V3 = 38 V, some domains are the remaining domains are switched to the focal conic state during the pulse. Constitutively activated R-Ras(38V) dramatically enhanced focal adhesion kinase (FAK) and pCas phosphorylation upon collagen stimulation or clustering.

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Stimulation of cells by collagen in suspension or by fkcal to collagen does not alter enhancement of FAK and p Cas phosphorylation by R-Ras 38V. Found this product in other categories: To further define the effects of R-Ras on FAK phosphorylation, phospho-specific antibodies that recognize the different phosphorylation sites of FAK were used.

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Lina KwongMichele A. This finding suggests a fundamental difference in the function of FAK and p Casas well as differences in signaling from R-Ras to each. Like the phosphorylation events, the formation of focal adhesions in cells expressing 38vv 38V was much less sensitive to the effects of PP2 than in control cells or cells expressing K-Ras 12V.

We previously demonstrated that R-Ras enhances cell migration via X4C2 and that cell surface expression of X4C2 is similar in control and R-Ras-expressing cells Cell migration demonstrated a similar trend, since PP2 partially inhibited R-Ras-induced cell migration Fig.

Biconvex Lens – 38mm – Focal Length mm – MTA Catalogue

FAK and p Cas phosphorylation was similar whether cells were stimulated with 38c in suspension or by adhesion to collagen-coated dishes, demonstrating that the enhancement of FAK and p Cas phosphorylation is independent of cell shape and does not rely on focal adhesion formation Fig.


Slides were viewed with a Nikon Eclipse TE inverted microscope.

Identification of pCas as a mediator of focal adhesion kinase-promoted cell migration. Integrins regulate several aspects of cell growth, migration, differentiation, and transformation.

The plate was air dried, and the amount of 32 P incorporated into PI phosphate was determined by autoradiography. We do not yet know the exact molecular mechanism for this synergy. Required role of focal adhesion kinase FAK for integrin-stimulated cell migration.

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R-Ras effector loop constructs, i. Collectively, these results suggest that there are Src-dependent and Src-independent pathways in R-Ras signaling to FAK, p Casfocal adhesion formation, and cell migration.

Although R-Ras increases breast epithelial cell adhesion to collagen, we think this is also through changes in avidity, not just conformational changes related to altered affinity Fig. View Saved Carts to access any items you may have previously added to your cart. Moreover, if R-Ras effects were strictly due to enhanced integrin affinity or avidity, we would expect that FAK and p Cas phosphorylation would be completely Src and actin dependent, as is the case for their phosphorylation downstream of integrins 253336but this was not the case Fig.

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Biconvex Lens – 38mm – Focal Length 100mm

Importantly, R-Ras signals to FAK and p Cas by a mechanism that is not due merely to enhanced integrin ligand binding, although it collaborates with integrin signaling. Cells were detached from tissue culture dishes by using 0.


Similar results were obtained for FAK data not shown and when cells adhered to plates coated with P1E6 antibody not shown. After being rinsed again in PBS, paraformaldehyde was quenched with 0. FAK and p Cas appear to be necessary 38vv of focal adhesion dynamics and the promotion 83v cell migration 2111418 Integrin transmembrane signaling and cytoskeletal control.

The graph represents the percentage of transfected cells able to form focal adhesions. When light reaches the lens in a straight line, the lens will bend the light rays to a specific focal point.

D Numerical population analysis of the experiment shown in panel C. Ras and Rho protein induction of motility and invasion in T47D breast adenocarcinoma cells.

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This focal point is lens-dependent and is different for the lenses included in the set. These data suggest that R-Ras can signal to FAK and p Cas independent of the integrity of the actin cytoskeleton, whereas, in normal cells and cells expressing activated K-Ras, FAK and p Cas phosphorylation is dependent on the actin cytoskeleton. Support Center Support Center. On the right is an immunoblot of lysates from cells stably expressing the different R-Ras constructs, demonstrating similar levels of expression of each construct.

Cells expressing GFP were counted. Requirement of phosphatidylinositol 3-kinase in focal adhesion kinase-promoted cell migration.